About 31 results found for searched term "Con B-1" (1.893 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M21110 | Con B-1 | ALK |
| ConB-1 is a strongly selective ALK inhibitor with low toxicity to normal cells. | ||
| M1752 | MLN8237 (Alisertib) | Aurora Kinase |
| Alisertib | ||
| MLN8237 (Alisertib) is a second-generation, orally bioavailable, highly selective Aurora kinase A inhibitor with IC50 of 61 nM. | ||
| M1976 | Pomalidomide | Ligand for E3 Ligase |
| Actimid, CC-4047 | ||
| Pomalidomide is the third-generation immunomodulatory agent, functions through interacting with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors. Pomalidomide is a second generation immunomodulator, TNF-α inhibitor with IC50 of 13 nM. | ||
| M25536 | Recombinant Human CXCL13/BCA-1 (E. coli) | Recombinant Proteins |
| CXC chemokine BLC; Small-inducible cytokine B13 | ||
| CXCL13, also known as B-lymphocyte chemoattractant (BLC), is a CXC chemokine that is constitutively expressed in secondary lymphoid organs. Recombinant human CXCL13 is a single non-glycosylated polypeptide chain containing 87 amino acids and mature human BCA-1 shares 64 % amino acid sequence similarity with the murine protein and 23–34 % amino acid sequence identity with other known CXC chemokines. Determined by a chemotaxis bioassay using human B cells, the biological activity is in a concentration range of 1.0-10 ng/ml. | ||
| M2892 | NSC697923 | E1/E2/E3 Enzyme |
| NSC697923 is a cell-permeable and selective inhibitor of the Ub-conjugating enzyme (E2) complex Ubc13-Uev1A. | ||
| M3192 | TRAM-34 | Potassium Channel |
| Triarylmethane-34 | ||
| TRAM-34 is a selective and potent inhibitor of the intermediate-conductance Ca2+-activated K+ channel (IKCa1, KCa3.1) with Kd of 20 nM, 200- to 1500-fold selective over other ion channels, and does not block cytochrome P450. | ||
| M3325 | Captopril | Animal Modeling |
| SQ 14225 | ||
| Captopril is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 6 nM. It can be used to construct animal models of heart failure. Captopril is also a New Delhi metallo-β-lactamase-1 (NDM-1) inhibitor with an IC50 of 7.9 μM. | ||
| M3426 | Enalaprilat Dihydrate | ACE |
| Enalaprilat is an angiotensin-converting enzyme (ACE) inhibitor with IC50 of 1.94 nM. | ||
| M25394 | BPTF-IN-1 | Epigenetic Reader Domain |
| compound AU1 | ||
| BPTF-IN-1 (compound AU1) is a selective bromodomain and PHD finger containing transcription factor (BPTF) bromodomain inhibitor with a Kd of 2.8 μM. BPTF-IN-1 shows to be selective for BPTF over BRD4 bromodomain. | ||
| M3524 | BRL-15572 dihydrochloride | 5-HT Receptor |
| BRL-15572 2HCl | ||
| BRL-15572 is a 5-HT1D receptor antagonist with pKi of 7.9, also shows a considerable affinity at 5-HT1A and 5-HT2B receptors, exhibiting 60-fold selectivity over 5-HT1B receptor. | ||
| M3595 | Gentamicin Sulfate | Animal Modeling |
| Gentamycin Sulfate; Gentacycol | ||
| Gentamicin Sulfate is a broad-spectrum aminoglycoside antibiotic that can be used in cell culture, as well as in the construction of animal models of chronic pelvic inflammatory disease. In addition, Gentamicin sulfate is also a potent DNase I inhibitor with an IC50 value of 0.57 ± 0.12 mM. | ||
| M3757 | Obatoclax Mesylate | Bcl-2 |
| GX15-070, Obatoclax | ||
| Obatoclax is an antagonist of Bcl-2 family members containing four Bcl-2 homology domains, including Bcl-2, Bcl-W, Bcl-XL, and Mcl-1 (KD = ~500 nM). | ||
| M3953 | Voriconazole | Cytochrome P450 (e.g. CYP17) |
| UK-109496 | ||
| Voriconazole (UK-109496) is an inhibitor of 14α-lanosterol demethylase with IC50 value of 53 nM. Voriconazole (UK-109496) is also a second-generation, broad-spectrum triazole antifungal agent that inhibits fungal ergosterol biosynthesis. | ||
| M11227 | FM-479 | JAK |
| Fm-479 was a negative control of FM-381 and showed no activity against JAK3 or other kinases. Fm-381 is a potent covalent reversible inhibitor of JAK3 targeting unique Cys909. For JAK3, FM-381 was 410, 2700 and 3600 times more selective than JAK1, JAK2 and TYK2 with IC50 of 127 pM. | ||
| M4011 | Echinatin | Others |
| Echinatin is isolated from the Chinese herbal medicine licorice, chalcone, which has liver protection and anti-inflammatory effects. In rats, Echinatin can be rapidly absorbed and eliminated and is widely distributed, with an absolute bioavailability of about 6.81%. | ||
| M4372 | Gypenoside XLIX | PPAR |
| Gypenoside XLIX is a dammarane-type glycoside, the main constituent of G. pentaphyllum. Gypenoside XLIX is a selective PPAR-α activator that inhibits cytokine-induced VCAM-1 overexpression in human endothelial cells and hyperactive. | ||
| M4717 | Usnic-acid | Antibiotic |
| Usnic acid is a lichen secondary metabolite with a unique dibenzofuran skeleton. Usnic acid has excellent anti-cancer and antibacterial properties. Usnic acid significantly inhibited ranKL-mediated osteoclast formation and function by decreasing transcription and translational expression of NFATc1. | ||
| M4846 | CC0651 | E1/E2/E3 Enzyme |
| CC 0651, CC-0651 | ||
| CC0651 is an allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme and inhibited the ubiquitination of p27Kip1 with IC50 value of 1.72 μM. | ||
| M5166 | Conivaptan hydrochloride | Vasopressin Receptor |
| Conivaptan HCl, Vaprisol, YM 087 | ||
| Conivaptan hydrochloride is a non-peptide vasopressin receptor antagonist, which can inhibit V1A receptor in rat liver and V2 receptor in kidney with Ki values of 0.48 and 3.04 nM, respectively. | ||
| M5269 | GSK180736A | ROCK |
| GSK180736 | ||
| GSK180736A, developed as a Rho-associated, coiled-coil-containing protein kinase inhibitor, binds to GRK2(G protein-coupled receptor kinase 2) with logIC50 pf -6.6 (logIC50 -4.0 for GRK5 and >-3 for GRK1); ≥400-fold selective for GRK2 over both GRK1 and GRK5. | ||
| M5472 | Butoconazole nitrate | Anti-infection |
| RS-35887 | ||
| Butoconazole (RS-35887) is an antifungal agent that inhibits phA-stimulated secretion of cytokines such as IL-2, TNFα, IFN and GM-CSF in human peripheral blood lymphocytes. IC50 were 7.2 μg/mL, 14.4 μg/mL, 7.36 μg/mL and 7.6 μg/mL, respectively. | ||
| M5482 | CB1954 | Others |
| Tretazicar | ||
| CB1954(Tretazicar) is a anticancer prodrug that is converted in the presence of the enzyme NQO2 and co-substrate caricotamide ( EP-0152R) (EP) into a potent cytotoxic bifunctional alkylating agent. It can be activated by NAD(P)H quinone oxidoreductase 2. | ||
| M5506 | Cetirizine Dihydrochloride | Histamine Receptor |
| P071; Cetirizine Di | ||
| Cetirizine 2Hcl, a second-generation antihistamine, is a major metabolite of hydroxyzine, and a racemic selective H1 receptor inverse agonist used in the treatment of allergies, hay fever, angioedema, and urticaria. | ||
| M5581 | Diniconazole | Antibiotic |
| Rac-diniconazole | ||
| Diniconazole is a newly developed fungicide strongly inhibited lanosterol 14 alpha-demethylation catalyzed by a yeast cytochrome P-450. | ||
| M5696 | Hydroquinidine | Others |
| Dihydroquinidine, Hydroconchinine, Hydroconquinine, Dihydroquinine | ||
| Hydroquinidine (Dihydroquinidine, Hydroconchinine, Hydroconquinine, Dihydroquinine) is a multichannel blocker with anticancer and antimalarial activity, acting on Plasmodium with a median IC50 of 129 nM, and can be used in studies related to short QT and Brugada arrhythmia syndrome. | ||
| M5719 | Itraconazole | Antibiotic |
| R 51211 | ||
| Itraconazole is a relatively potent inhibitor of CYP3A4 with IC50 of 6.1 nM, used as a triazole antifungal agent. | ||
| M5731 | LCZ696 | Angiotensin Receptor |
| Sacubitril/Valsartan；Entresto | ||
| LCZ696, consisting of Valsartan and Sacubitril in a 1:1 molar ratio, is a first-in-class dual-action angiotensin receptor-neprilysin inhibitor (ARNi,angiotensin receptor-neprilysin inhibitor) for the study of hypertension and heart failure. | ||
| M6046 | Uridine | DNA/RNA Synthesis |
| NSC 20256 | ||
| Uridine is a nucleoside, contains a uracil attached to a ribose ring via a β-N1-glycosidic bond. | ||
| M6240 | Angiotensin II human | Animal Modeling |
| Angiotensin II; Hypertensin II; Ang II; DRVYIHPF | ||
| Angiotensin II human is converted by Angiotensin I through removal of two C-terminal residues by the enzyme angiotensin-converting enzyme (ACE). Angiotensin II is mediated by AT1 and AT2 receptors, which are seven transmembrane glycoproteins with 30% sequence similarity. Keep away from light and prepare for use now. | ||
| M6621 | Conantokin-R | Others |
| Con-R | ||
| Conantokin-R is a potent, non-competitive NMDA receptor peptide antagonist with an IC50 of 93 nM.Conantokin-R is also NR2 subunit selective. It inhibits the inward current induced by NMDA in CNS neurons (IC50 = 350 nM). In addition, Conantokin R bound to Zn2+ and Mg2+ with Kd of 0.15 μM and 6.5 μM, respectively. | ||
| M6710 | Endoxifen Z-isomer hydrochloride | Estrogen Receptor |
| Endoxifen Z-isomer HCl | ||
| Endoxifen Z-isomer hydrochloride is a Tamoxifen metabolite and a potent estrogen receptor (ER) antagonist that concentration-dependently inhibits hERG with an IC50 value of 1.6 μM. | ||
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